发明名称 |
Stabilized lyophilized compositions comprising tissue factor pathway inhibitor or tissue factor pathway inhibitor variants |
摘要 |
Lyophilized compositions of TFPI or a TFPI variant suitable for long-term storage can be formed by lyophilizing an aqueous formulation of the TFPI or TFPI variant having a pH from about 4 to about 8 with a carbohydrate or amino acid glass forming agent. These lyophilized compositions are stable for greater than three months when stored at 40° C.
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申请公布号 |
US2006159679(A1) |
申请公布日期 |
2006.07.20 |
申请号 |
US20060385873 |
申请日期 |
2006.03.22 |
申请人 |
CHIRON CORPORATION |
发明人 |
CHEN BAO-LU;HORA MANINDER |
分类号 |
A61K39/395;A61K9/19;A61K31/7012;A61K31/715;A61K38/17;A61K38/57;A61K47/18;A61K47/26 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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