发明名称 |
Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer |
摘要 |
A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2'-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
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申请公布号 |
US2006159619(A1) |
申请公布日期 |
2006.07.20 |
申请号 |
US20050250830 |
申请日期 |
2005.10.14 |
申请人 |
BECKER MATTHEW L;FANG HUAFENG;LI XIAOXU;PAN DIPANJAN;ROSSIN RAFFAELLA;SUN XIANKAI;TAYLOR JOHN-STEPHEN;TURNER JEFFREY L;WELCH MICHAEL J;WOOLEY KAREN L |
发明人 |
BECKER MATTHEW L.;FANG HUAFENG;LI XIAOXU;PAN DIPANJAN;ROSSIN RAFFAELLA;SUN XIANKAI;TAYLOR JOHN-STEPHEN;TURNER JEFFREY L.;WELCH MICHAEL J.;WOOLEY KAREN L. |
分类号 |
A61K51/00;A61K48/00;C12Q1/68 |
主分类号 |
A61K51/00 |
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