Pyrrolopyrimidinone derivatives

摘要

A compound having GSK-3 inhibitory activity. A¹ and A³ are a single bond, an aliphatic hydrocarbon group; A² and A⁴ are a single bond, CO, COO, CONR, O, OCO, NR, NRCO, NRCOO, etc.; G¹ is a single bond, an aliphatic hydrocarbon, aromatic hydrocarbon, heterocyclic; G² is H, an aliphatic hydrocarbon, an alicyclic hydrocarbon, an aromatic hydrocarbon, heterocyclic; A⁵ is a single bond, NR; R² is H, halogen, an aliphatic hydrocarbon, alicyclic hydrocarbon, aromatic hydrocarbon, heterocyclic; A⁶ is a single bond, NR, CO, NRCO, NRCONR, CONR, COO, O, etc.; R³ is H, halogen, nitro, saturated aliphatic hydrocarbon, alicyclic hydrocarbon, aromatic hydrocarbon, heterocyclic; and R³ may be a trimethylsilyl, formyl, acyl, carboxyl, alkoxylcarbonyl, carbamoyl, alkylcarbamoyl, or cyano group when A⁶ is CR-CR or C≡C, wherein R is H or an lower aliphatic hydrocarbon group.