TOPICAL FORMULATIONS FOR THE TREATMENT OF DEPRESSION WITH S ADENOSYL METHIONINE

摘要

Disclosed herein are topical formulations for treating depression with S adenosyl methionine (SAM-e). The topical formulations contain at least 35% wt/wt of SAM-e partially dissolved in aqueous and lipophilic phases of an emulsion and the emulsion is stable from separation of phases for a period of at least 30 days despite the high concentration of SAM-e. Also provided are methods for making such compositions and methods of treating depression using the same.