发明名称 |
Inhibitors of nucleoside phosphorylases and nucleosidases |
摘要 |
The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5'-methylthioadenosine phosphorylases (MTAP), 5'-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.
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申请公布号 |
US2006160765(A1) |
申请公布日期 |
2006.07.20 |
申请号 |
US20050524995 |
申请日期 |
2005.09.27 |
申请人 |
EVANS GARY B;HUBERT RICHARD;LENZ DIRK H;SCHRAMM VERN L;TYLER PETER C;ZUBKOVA OLGA V |
发明人 |
EVANS GARY B.;HUBERT RICHARD;LENZ DIRK H.;SCHRAMM VERN L.;TYLER PETER C.;ZUBKOVA OLGA V. |
分类号 |
A61K31/7076;A61K31/519;A61K31/655;A61P31/04;A61P33/02;A61P35/00;A61P37/02;C07D487/02;C07H19/16;C07H19/23 |
主分类号 |
A61K31/7076 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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