Methods of designing small interfering RNAs, antisense polynucleotides, and other hybridizing polynucleotides

摘要

The present invention relates to methods, apparatus and computer program products for selecting siRNAs, antisense polynucleotides, and other hybridizing polynucleotides. In particular, the invention relates to methods for selecting siRNAs, antisense polynucleotides, and other hybridizing polynucleotides that have moderate or low off-target activity.