PROCESS FOR PRODUCING OPTICALLY ACTIVE ß-HYDROXY-a-AMINOCARBOXYLIC ACID DERIVATIVE

摘要

[PROBLEMS] To provide a process for efficiently producing the anti isomer of an optically active ß-hydroxy-a-aminocarboxylic acid derivative useful as an intermediate for medicines/agricultural chemicals. [MEANS FOR SOLVING PROBLEMS] The process, which is for producing an optically active ß-hydroxy-a-aminocarboxylic acid derivative represented by the formula (2) or (3) [Chemical formula 3] (wherein R¹ means (un)substituted C_1-20 alkyl or an (un)substituted C_4-12 aromatic group and R² means (un)substituted C_1-20 alkyl or an (un)substituted C_4-12 aromatic group), comprises hydrogenating an a-aminoacylacetic ester compound represented by the formula (1): [Chemical formula 1] [wherein R¹ and R² have the same meanings as defined above] in the presence of an acid through a catalytic asymmetric hydrogenation reaction employing as a catalyst a rhodium complex having as a ligand an optically active compound represented by the formula (4), (4'), or (5): [Chemical formula 2] the process being characterized in that the hydrogenation is conducted in the presence of an acetic acid salt.