Matrix metalloproteinase inhibitors

摘要

Compounds of formula (I): wherein: Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X represents O, S, NR⁵ or CR⁶ R⁷; Y represents CHOH, CHSH, NOR⁸, CNR⁸ or CNOR⁸; Z represents a bond, CR¹⁰R¹¹, O, S, SO, SO₂, NR¹⁰, OCR¹⁰R¹¹, CR¹⁰R¹¹ O or Z, R⁴ and Q together form an optionally substituted fused tricyclic group; R¹, R^1', R³ and R^3' each independently represents H, C_1-6 alkyl or C_1-4 alkylaryl; R² represents CO₂R⁸, CONR⁵OR⁹ or NR⁵COR⁹; R⁴ represents optionally substituted 5- or 6-membered aryl or heteroaryl; R⁵ represents H or C_1-3 alkyl; R⁶ and R⁷ each independently represents H, C_1-3 alkyl or halo; R⁸ represents H or C_1-2 alkyl; R⁹ represents H or C_1-3 alkyl; R¹⁰ and R¹¹ each independently represents H, C_1-6 alkyl or C_1-4 alkylaryl; and physiologically functional derivatives thereof, processes for their preparation, pharmaceutical formulations containing them and their use as inhibitors of matrix metalloproteinase enzymes (MMPs) are described.