发明名称 |
PHENYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS |
摘要 |
The present invention relates generally to phenylglycinamide derivatives that inhibit serine proteases. In particular it is directed to novel phenylglycinamide derivatives, and analogues thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same. |
申请公布号 |
WO2006076246(A2) |
申请公布日期 |
2006.07.20 |
申请号 |
WO2006US00571 |
申请日期 |
2006.01.09 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;ZHANG, XIAOJUN;PRIESTLEY, ELDON SCOTT;NIRSCHL, ALEXANDRA A.;ZOU, YAN |
发明人 |
ZHANG, XIAOJUN;PRIESTLEY, ELDON SCOTT;NIRSCHL, ALEXANDRA A.;ZOU, YAN |
分类号 |
C07D401/12;A61K31/40;A61K31/4725;C07D207/14 |
主分类号 |
C07D401/12 |
代理机构 |
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地址 |
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