QUERVERNETZTE STARK AMYLOSE HALTIGE STÄRKE ZUR VERWENDUNG IN PHARMAZEUTISCHEN FORMULIERUNGEN MIT KONTROLLIERTER FREISETZUNG UND VERFAHREN ZU IHRER HERSTELLUNG
摘要
The present invention relates to a novel form of cross-linked high amylose starch and processes for its manufacture. Such cross-linked high amylose starch is useful as an excipient in a controlled-release pharmaceutical formulation when compressed with pharmaceutical agent(s) in a tablet. Such cross-linked high amylose starch is prepared by (a) cross-linking and chemical modification of high amylose starch, (b) gelatinization, and (c) drying to obtain a powder of said controlled release excipient. In a preferred embodiment, such cross-linked high amylose starch is prepared in the following steps: (1) granular cross-linking and additional chemical modification (e.g., hydroxypropylation) of high-amylose starch; (2) thermal gelatinization of the starch from step (1); and (3) drying the starch from step (2) to yield a powder capable of being used as a controlled release excipient.
申请公布号
DE60120413(D1)
申请公布日期
2006.07.20
申请号
DE2001620413
申请日期
2001.06.26
申请人
LENAERTS, VINCENT;BECK, ROLAND HERWIG FRIEDRICH;BOGAERT, ELSIE VAN;CHOUINARD, FRANCOIS;HOPCKE, REINER;DESEVAUX, CYRIL
发明人
LENAERTS, VINCENT;BECK, ROLAND HERWIG FRIEDRICH;BOGAERT, ELSIE VAN;CHOUINARD, FRANCOIS;HOPCKE, REINER;DESEVAUX, CYRIL