发明名称 |
Osmotic device containing amantadine and an osmotic salt |
摘要 |
The osmotic devices of the present invention contain a unitary core comprising a salt of amantadine and an osmotic salt, wherein the two salts have an ion in common. The release rate of the amantadine is modified from a first order release profile to a zero order, pseudo-zero order or sigmoidal release profile by increasing the amount of the osmotic salt in the core of the device. The osmotic device includes a semipermeable membrane having a controlled porosity that can be adapted as needed to cooperate with the osmotic salt in providing a predetermined drug release profile. The osmotic salt need not be coated and it is in admixture with the amantadine salt.
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申请公布号 |
US2006159763(A1) |
申请公布日期 |
2006.07.20 |
申请号 |
US20050287882 |
申请日期 |
2005.11.28 |
申请人 |
MEYER GLENN A;FELEDER ETHEL C;RICCI MARCELO A;COPPARI MARCELO A;BEFUMO MARCELO F;FAOUR JOAQUINA;VERGEZ JUAN A |
发明人 |
MEYER GLENN A.;FELEDER ETHEL C.;RICCI MARCELO A.;COPPARI MARCELO A.;BEFUMO MARCELO F.;FAOUR JOAQUINA;VERGEZ JUAN A. |
分类号 |
A61K31/13;A61K9/24 |
主分类号 |
A61K31/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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