摘要 |
Nonmetallic, chiral organic catalysts are used to catalyze the 1,4-hydride reduction of an alpha,beta-unsaturated carbonyl compound. The alpha,beta-unsaturated carbonyl compound may be an aldehyde or cyclic ketone, and the hydride donor may be a dihydropyridine. The reaction is enantioselective, and proceeds with a variety of hydride donors, catalysts, and substrates. The invention also provides compositions effective in carrying out the 1,4-hydride addition of alpha,beta-unsaturated carbonyl compounds.
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