PHARMACEUTICAL COMPOSITION COMPRISING A P25/CDK5 INHIBITOR FOR PREVENTING OR TREATING A NEURODEGENERATIVE DISEASE

摘要

A pharmaceutical composition for preventing or treating a neurodegenerative disease comprises a compound inhibiting a P25/CDK (cycline-dependent kinase 5) complex as an active ingredient. Also disclosed is a method for screening a compound capable of preventing or treating a neurodegenerative disease, which comprises the steps of a) reacting a candidate compound with a P25/CDK5 complex and beta-site APP (amyloid precursor protein)-cleaving enzyme 1 (BACEl) or treating a mammalian cell expressing P25 with the candidate compound, and measuring BACE l phosphorylation; and b) comparing the measured BACEl phosphorylation with that of a control group employing no candidate compound, and identifying a compound reducing BACEl phosphorylation compared to the control group. The compound inhibiting the P25/CDK5 complex may be useful for preventing or treating a neurodegenerative disease including Alzheimer's disease because it inhibits BACEl phosphorylation and reduces the secretion of ß-amyloid and the hyperphosphorylation of Tau.