SITE-SPECIFIC INTESTINAL DELIVERY AND/OR PRODUCTION OF BIOLOGICALLY ACTIVE SUBSTANCES

摘要

The present invention relates to the site-specific production of biologically active substances by recombinant micro-organisms in body cavities of a human or animal subject. The invention provides transcription regulatory sequences, which are specifically induced in the gastrointestinal tract (GI-tract) of subjects and methods for their use for in vivo site-specific expression of nucleic acid sequences encoding biologically active substances.