发明名称 |
MOUSE MODEL WHEREIN RESPONSIVENESS TO LIPOPOLYSACCHARIDE (LPS) IS SPECIFICALLY IMPAIRED |
摘要 |
The present invention is to provide a non-human animal model non-responsive especially to endotoxin being a Gram-negative bacteria cell wall fraction, which is useful to elucidate the function of TIR domain-containing TRIF-related adaptor molecule (TRAM); and a method for screening substances promoting or suppressing responses to ligands recognized by TLR4 with the use of the non-human animal model non-responsive to endotoxin; and the like. Mice non-responsive to the endotoxin wherein a part or a whole of Tram genes on their chromosome are deleted, the function to express TRAM which is expressed in wild-types is lacked, and the responsiveness to ligands recognized by TLR4 is specifically impaired; is used for screening substances promoting or suppressing responses to ligands recognized by TLR4.
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申请公布号 |
EP1680959(A1) |
申请公布日期 |
2006.07.19 |
申请号 |
EP20040788287 |
申请日期 |
2004.09.29 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
AKIRA, SHIZUO;YAMAMOTO, MASAHIRO |
分类号 |
A01K67/027;C12N15/09;C12Q1/02;G01N33/15;G01N33/50;(IPC1-7):A01K67/027 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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