RADIATION DOSIMETRY AND BLOCKING ANTIBODIES AND METHODS AND USES THREFOR IN THE TREATMENT OF CANCER

摘要

Disclosed is a method for dosimetry estimation for a region of interest at or around a surgically created resection cavity in a subject. These methods enable medical practitioners to estimate the amount of administered Radioimmunotherapy (RIT) agent needed to safely and effectively achieve a final Radiation Absorbed Dose (RAD). Furthermore, computer hardware and software are provided herein, so that the methods according to the invention may be automated for more efficient use. Also disclosed is a method of enhancing delivery of therapeutic antibodies that specifically bind to an extracellular stromal constituent of a tumor in a mammalian subject. The method comprises administering to a subject an effective dosage of a blocking antibody, said blocking antibodies specifically binding to said extracellular stromal constituent and blocking the binding of therapeutic antibodies to non-target tissue.