N-phenyl-3-cyclopropylpyrazole-4-carbonitriles as ectoparasiticidal agents

摘要

A method and composition for the prevention, amelioration or control of external parasites on animals and humans utilizing a compound of formula I. or a pharmaceutically acceptable salt thereof, wherein R is halogen, OR₇, SO_mR₈, NO₂, CN, C₁-C₆haloalkyl or an optionally substituted C₁-C₆alkyl group; n is 0 or an integer of 1, 2 or 3; m is 0 or an integer of 1 or 2; R₁ is H, halogen, NO₂, NR₉R₁₀, NR₁₁COR₁₂, NCHNR₉R₁₀ or NCHOR₁₃; R₂, R₃, R₄, R₅ and R₆ are each independently H, halogen or a C₁-C₄alkyl, aryl or heteroaryl group each optionally substituted; R₇ is H or a C₁-C₆alkyl, C₂-C₆alkenyl, C₂-C₆alkynyl, aryl or heteroaryl group each optionally substituted; R₈ is a C₁-C₆alkyl, C₂-C₆alkenyl, C₂-C₆alkynyl, aryl or heteroaryl group, each optionally substituted; R₉ and R₁₀ are each independently H, C₁-C₄haloalkyl or a C₁-C₆alkyl, C₂-C₆alkenyl, C₂-C₆alkynyl, aryl or heteroaryl group each optionally substituted or R₉ and R₁₀ may be taken together with the atom to which they are attached to form a 5 to 7-membered ring optionally containing 1 or 2 additional heteroatoms selected from O, N or S; R₁₁ is H, COR₁₂ or an optionally substituted C₁-C₄alkyl group; R₁₂ is a C₁-C₆alkyl, C₂-C₆alkenyl, C₂-C₆alkynyl, aryl or heteroaryl group each optionally substituted; and R₁₃ is H or a C₁-C₆alkyl, aryl or heteroaryl group each optionally substituted; or a stereoisomer or tautomer thereof.