摘要 |
A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a KINASE polypeptide, or fragment thereof, and measuring a compound-KINASE property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including phosphorylated kinase substrate and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processinginhibiting amounts of KINASE expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimer's disease. |
申请人 |
GALAPAGOS N.V.;LAENEN, WENDY;SPITTAELS, KOENRAAD, FREDERIK, FLORENTINA;HOFFMANN, MARCEL;MERCHIERS, PASCAL, GERARD |
发明人 |
SPITTAELS, KOENRAAD, FREDERIK, FLORENTINA;HOFFMANN, MARCEL;MERCHIERS, PASCAL, GERARD |