发明名称 |
Diagnosis and treatment of breast cancer |
摘要 |
Methods and compositions are provided for the identification of expression signatures in ER+ breast cancer cases, where the signatures correlate with responsiveness, or lack thereof, to treatment with tamoxifen or another antiestrogen agent against breast cancer The signature profiles are identified based upon sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for predicting the efficacy of treating a subject with breast cancer with tamoxifen or another antiestrogen agent against breast cancer. Additional methods and compositions are provided for predicting responsiveness to tamoxifen or another antiestrogen agent against breast cancer in cases of breast cancer by use of multiple biomarkers. Two biomarkers display increased expression correlated with tamoxifen response while two other biomarkers display decreased expression correlated with tamoxifen response.
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申请公布号 |
US2006154267(A1) |
申请公布日期 |
2006.07.13 |
申请号 |
US20050089097 |
申请日期 |
2005.03.24 |
申请人 |
ARCTURUS BIOSCIENCE, INC. |
发明人 |
MA XIAO-JUN;ERLANDER MARK G.;SGROI DENNIS C.;ENRIGHT EDWARD |
分类号 |
G06Q10/00;C12Q1/68;G06Q50/00 |
主分类号 |
G06Q10/00 |
代理机构 |
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代理人 |
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地址 |
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