PALLADIUM CATALYZED INDOLIZATION OF 2-BROMO OR CHLOROANILINES
摘要
The present invention provides a method for making substituted indole compounds of general formula III comprising the step of: (a) reacting a 2-bromoaniline or 2-chloroaniline of general formula (I); wherein: X, R and R1 are defined herein with a substituted acetylene of formula (II); wherein R2 and R3 in the presence of a palladium catalyst, a ligand, and a base in a solvent at a suitable temperature to give a compound of formula (III)
申请公布号
WO2005090302(A3)
申请公布日期
2006.07.13
申请号
WO2005US08620
申请日期
2005.03.14
申请人
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;LI, GUISHENG;LIU, JIANXIU;LU, ZHI-HUI;ROSCHANGAR, FRANK;SENANAYAKE, CHRIS, HUGH;SHEN, MING
发明人
LI, GUISHENG;LIU, JIANXIU;LU, ZHI-HUI;ROSCHANGAR, FRANK;SENANAYAKE, CHRIS, HUGH;SHEN, MING