| 摘要 |
PROBLEM TO BE SOLVED: To obtain an agent for diagnosing, preventing and treating adhesion and to provide a method for diagnosing, preventing and treating adhesion. SOLUTION: The medicine composition for preventing or treating adhesion comprises a CCR8 inhibitor as an active ingredient. The CCR8 inhibitor is preferably selected from the group consisting of an antibody binding to CCR8, a neutralizing antibody against a CCR8 ligand CCL1, aptamers to CCR8 and CCL1, an antagonist to CCR8, antisense oligonucleotides to CCR8 and CCL1 genes and siRNAs thereto. The method of diagnosing adhesion comprises detecting the expression of a CCR8 gene or a CCL1 gene in test cells or detecting the content of CCR8 or CCL1 in the test cells. The screening method comprises screening a substance which is useful in preventing and treating adhesion. COPYRIGHT: (C)2006,JPO&NCIPI
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