发明名称 |
Antitumoral d-homoestra-1,3,5 (10)-trien-3-yl 2-substituted sulfamates |
摘要 |
This invention relates to 2-substituted D-homo-estra-1,3,5(10)-trien-3-yl sulfamates of general formula I (I), in which R3 means a C1-C5-alkyl or C1-C5-alkyloxy group as well as their use for the production of a pharmaceutical agent for treating tumor diseases, which can be influenced positively by the inhibition of tubulin polymerization. The compounds according to the invention are distinguished by a D-homosubstitution. They have a special action with respect to tubulin polymerization inhibition and can be used, for example, for treating prostate cancer.
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申请公布号 |
US2006154985(A1) |
申请公布日期 |
2006.07.13 |
申请号 |
US20050546230 |
申请日期 |
2005.08.18 |
申请人 |
HILLISCH ALEXANDER;PETERS OLAF;GEGE CHRISTIAN;SIEMEISTER GERHARD;UNGER EBEHARD;MENZENBACH BERND |
发明人 |
HILLISCH ALEXANDER;PETERS OLAF;GEGE CHRISTIAN;SIEMEISTER GERHARD;UNGER EBEHARD;MENZENBACH BERND |
分类号 |
A61K31/255;A61K31/565;A61P35/00;C07J31/00;C07J41/00;C07J63/00 |
主分类号 |
A61K31/255 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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