发明名称 |
Process for the preparation of an improved Brucella strain plasmid to develop the strain and the vaccine comprising the said strain |
摘要 |
A Brucella bacterium is modified by partial or complete deletion of the pgm gene, rendering the bacterium incapable of synthesizing a key enzyme in the metabolism of bacterial sugars. A live vaccine for immunization, prophylaxis or treatment of brucellosis comprises such a bacterium, either lyophilized or in a pharmaceutical vehicle. Nucleotide sequence fragments having the aforementioned deletion are disclosed, with methods for making them.
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申请公布号 |
US2006153868(A1) |
申请公布日期 |
2006.07.13 |
申请号 |
US20040978244 |
申请日期 |
2004.10.28 |
申请人 |
UGALDE JUAN E;COMERCI DIEGO J;UGALDE RODOLFO A;DEL VECCHIO VITO G |
发明人 |
UGALDE JUAN E.;COMERCI DIEGO J.;UGALDE RODOLFO A.;DEL VECCHIO VITO G. |
分类号 |
A61K39/02;C12N1/21;C12N15/74 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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