METHODS FOR DOSE SELECTION OF LIPOSOMAL ENCAPSULATED SN38

摘要

The present invention is directed to methods for determining pharmaceutically effective amounts of a liposomal formulation containing SN-38 (LE-SN38) by detecting polymorphisms within a uridine diphosphate glucuronosyltransferase (UGT1A1) gene. In accordance with the inventive method, LE-SN38 is administered at dosages of up to about 35 mg/m2 for individuals having at least one wild-type copy of the UGT1A1 allele and at dosages between about 20 mg/m2 to about 35 mg/m2 for individuals with no wild type UGT1A1 allele, such as dosages between about 20 mg/m2 to about 30 mg/m2.