发明名称 |
Leptin antagonists |
摘要 |
The invention relates to synthetic leptin antagonists in which at least two amino acid residues of the sequence LDFI/S of the hydrophobic binding site at positions 39-42 of a leptin polypeptide sequence are substituted with different amino acid residues such that the site becomes less hydrophobic, and fragments of said leptin antagonists.
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申请公布号 |
US2006154859(A1) |
申请公布日期 |
2006.07.13 |
申请号 |
US20040996607 |
申请日期 |
2004.11.26 |
申请人 |
INSTITUT NATIONALE DE LA RECHERCHE AGRONOMIQUE (INRA) |
发明人 |
GERTLER ARIEH;CALLEBAUT ISABELLE;DJIANE JEAN |
分类号 |
A61K38/17;C07H21/04;C07K14/47;C12P21/06 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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