摘要 |
The present invention provides C-purine nucleoside analogs and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such C-nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the C-nucleoside compounds of the present invention. |
申请人 |
MERCK & CO., INC.;ISIS PHARMACEUTICALS, INC.;BUTORA, GABOR;MACCOSS, MALCOLM;BHAT, BALKRISHEN;ELDRUP, ANNE, B. |
发明人 |
BUTORA, GABOR;MACCOSS, MALCOLM;BHAT, BALKRISHEN;ELDRUP, ANNE, B. |