发明名称 |
ALPHA-KETO CARBONYL CALPAIN INHIBITORS |
摘要 |
The present invention relates to novel a-keto carbonyl calpain inhibitors for the treatment of neurodegenerative diseases and neuromuscular diseases including Duchenne Muscular Dystrophy, Becker Muscular Dystrophy and other muscular dystrophies. Disuse atrophy and general muscle wasting can also be treated. Diseases of the eye, in particular cataract, can be treated as well. Generally all conditions where elevated levels of calpains are involved can be treated. The compounds of the invention may also inhibit other thiol proteases such as cathepsin B, cathepsin H, cathepsin L, papain or the like. Multicatalytic Protease (MCP) also known as proteasome may also be inhibited and the compounds can therefore be . used to treat cell proliferative diseases such as cancer, psoriasis, and restenosis. The compounds of the present invention are also inhibitors of cell damage by oxidative stress through free radicals and can be used to treat mitochondrial disorders and neurodegenerative diseases, where elevated levels of oxidative stress are involved. |
申请公布号 |
WO2004078908(A3) |
申请公布日期 |
2006.07.13 |
申请号 |
WO2004EP02142 |
申请日期 |
2004.03.03 |
申请人 |
SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH;HERZNER, HOLGER;WEYERMANN, PHILIPP;VON SPRECHER, ANDREAS;HENNEBOEHLE, MARCO;LESCOP, CYRILLE;SIENDT, HERVE |
发明人 |
HERZNER, HOLGER;WEYERMANN, PHILIPP;VON SPRECHER, ANDREAS;HENNEBOEHLE, MARCO;LESCOP, CYRILLE;SIENDT, HERVE |
分类号 |
A61K38/05;A61K38/00;A61P21/00;A61P25/28;C07D233/54;C07D333/24;C07D333/48;C07D339/04;C07D409/12;C07D495/04;C07K5/02;C07K5/06;C07K5/062;C07K5/065 |
主分类号 |
A61K38/05 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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