POLYETHYLENE GLYCOL LINKED MC4R OR MC3R AGONIST PEPTIDES

摘要

The invention provides MC4R or MC3R agonist peptides coupled to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated MC4R or MC3R agonist peptides and compositions are useful in treating obesity, diabetes, sexual dysfunction, cachexia, sarcopenia, dyslipidemia, to increase weight loss, or to increase muscle mass.