摘要 |
<p>The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) a (NR1H3) and/or ß (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.</p> |
申请人 |
ASTRAZENECA AB;BROO, ANDERS;HOLM, PATRIK;JUDKINS, ROBERT;LI, LANNA;LINDSTEDT-ALSTERMARK, EVA-LOTTE;SANDBERG, PERNILLA;SWANSON, MARIANNE;WEIDOLF, LARS;MRICKMANN, KAY |
发明人 |
BROO, ANDERS;HOLM, PATRIK;JUDKINS, ROBERT;LI, LANNA;LINDSTEDT-ALSTERMARK, EVA-LOTTE;SANDBERG, PERNILLA;SWANSON, MARIANNE;WEIDOLF, LARS;MRICKMANN, KAY |