发明名称 |
Liposomal benzoquinazoline thymidylate synthase inhibitor formulations |
摘要 |
Liposomal encapsulated benzoquinazoline thymidylate synthase inhibitor formulations are provided. The liposomes have improved pharmacokinetics and enhanced efficacy as anti-tumor agents compared to the free drug. The formulations include liposomes comprising at least one phosphatidylcholine, a cholesterol, and a benzoquinazoline thymidylate synthase inhibitor. |
申请公布号 |
AU2001275269(B2) |
申请公布日期 |
2006.07.13 |
申请号 |
AU20010275269 |
申请日期 |
2001.06.06 |
申请人 |
OSI PHARMACEUTICALS, INC. |
发明人 |
CLAUDINE S. ASHVAR;GERARD M. JENSEN;NING HU;SU-MING CHIANG;DAVID L. EMERSON |
分类号 |
A61K9/127;A61K31/513;A61K31/517;A61K45/00;A61K47/24;A61K47/28;A61P31/12;A61P35/00;A61P43/00 |
主分类号 |
A61K9/127 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|