PARTICLE ADJUVANT FOR HIFU THERAPY AND THE USE THEREOF

摘要

A particle adjuvant for HIFU therapy, which can increase energy deposition in target regions during the therapy, comprises a discontinuous phase consisting of a core encapsuled by a film-forming material and a continuous phase consisting of aqueous medium, wherein the discontinuous phase is well distributed in the continuous one; the particle size of the discontinuous phase is 0.1-8gm; the amount of the film-forming material in the adjuvant is 0.1-100g/L; the core material used is a liquid which will not transform into gas at 38-100^°C and is incorporated into the adj uvant in the amount of 5 -2 0 0ml /L . The adjuvant of fluorocarbon emulsions for HIFU therapy is capable of upgrading the acoustic environment of target regions remarkably, increasing energy deposition in target tissues during HIFU therapy, and consequently significantly improving the damaging effect against tumor cells during clinical HIFU. And the usage of such adjuvant in HIFU therapy.