SUPERAGONISTIC ANTI-CD28 ANTIBODY

摘要

The invention relates to a nucleic acid or several nucleic acids coding for a binding molecule which specifically binds a human CD28-molecule, comprising (a) a nucleic acid sequence coding for a V_H-region and a nucleic acid sequence coding for a V_L-region comprising CDRs in a human immunoglobulin structure, wherein (i) the CDRs of the VH-region (CDR-H) comprise the amino acid sequences of the SEQ ID NO: 2 or 18 (CDR-H3), 4 or 20 (CDR-H2) and 6 or 22 (CDR-H1) or are coded by the nucleic acid sequences of the SEQ ID NR: 1 or 17 (CDR-H3), 3 or 19 (CDR-H2) and 5 or 21 (CDR-H1); and (ii) the CDRs of the V_L-region (CDR-L) comprise the amino acid sequences of the SEQ ID NO: 8 or 24 (CDR-L3), 10 or 26 (CDR-L2) and 12 or 28 (CDR-L1) or are coded by the nucleic acid sequences of the SEQ ID NR: 7 or 23 (CDR-L3), 9 or 25 (CDR-L2) and 11 or 27 (CDR-L1); and (b) a nucleic acid sequence coding for a constant region of a human IgG1-or IgG4-antibody.