发明名称 |
METHODS AND COMPOSITIONS FOR PDGF-C ACTIVATION AND INHIBITION |
摘要 |
<p>Methods for inhibiting angiogenesis comprising administering tissue-plasminogen activator (tPA) inhibitors, and pharmaceutical compositions suitable for the methods comprising the tPA inhibitors. Also provided are methods for stimulating angiogenesis comprising administering tPA to a patient in need thereof, and pharmaceutical compositions comprising an effective amount of tPA for the methods of stimulation. The present invention discloses that tPA is a specific PDGF-C activating protease, and that the CUB-domains in PDGF-CC directly interact with the protease, are required for efficient proteolysis, and released CUB-domains are tPA inhibitors. Preferably, the method and compositions of the present invention are used for simultaneously stimulating, or simultaneously inhibiting, thrombolysis and angiogenesis.</p> |
申请公布号 |
EP1678197(A2) |
申请公布日期 |
2006.07.12 |
申请号 |
EP20040796267 |
申请日期 |
2004.10.25 |
申请人 |
LUDWIG INSTITUTE FOR CANCER RESEARCH |
发明人 |
FREDRIKSSON, LINDA;LI, HONG;FIEBER, CHRISTINA;LI, XURI;ERIKSSON, ULF |
分类号 |
A61K39/395;A61K38/16;A61K38/43;A61K38/55;A61P35/00;C07K;C07K14/49;C07K16/22;C07K16/40;C12N9/72;C12N9/99;C12Q1/37;(IPC1-7):C07K1/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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