发明名称 |
Use of integrin antagonists to inhibit angiogenesis |
摘要 |
The present invention provides methods and compositions for inhibiting the biological activity of integrins, for inhibiting endothelial cell migration. and for inhibiting angiogenesis. In particular, the invention provides compositions comprising ADAM disintegrin domains and methods for using said compositions. In preferred embodiments the methods and compositions of the invention are used to inhibit angiogenesis and to treat diseases or conditions mediated by angiogenesis.
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申请公布号 |
US7074408(B2) |
申请公布日期 |
2006.07.11 |
申请号 |
US20010792200 |
申请日期 |
2001.02.23 |
申请人 |
IMMUNEX CORPORATION |
发明人 |
FANSLOW, III WILLIAM C.;CERRETTI DOUGLAS P.;POINDEXTER KURT M.;BLACK ROY A. |
分类号 |
A61K35/00;C12N15/09;A61K38/00;A61K45/00;A61K51/00;A61P1/04;A61P3/10;A61P7/02;A61P9/10;A61P17/02;A61P17/06;A61P19/02;A61P19/10;A61P27/02;A61P27/06;A61P29/00;A61P31/04;A61P35/00;A61P35/04;A61P43/00;C07K14/46;C07K14/705;C07K19/00;C12N9/64;C12N15/57;C12P21/02;C12Q1/02 |
主分类号 |
A61K35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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