| 摘要 |
FIELD: organic chemistry, biochemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to new derivatives of piperidine of the general formula (I): wherein R represents (C1-C16)-alkyl or (C1-C10)-alkylphenyl wherein phenyl is optionally substituted with -OR1 wherein R1 represents (C1-C6)-alkyl, or their pharmaceutically acceptable salts. These compounds possess inhibitory activity with respect to enzyme glucosylceramide synthase and can be used in medicine in treatment of diseases caused by accumulation of glycolipid. ^ EFFECT: improved preparing method, valuable medicinal and biochemical properties of derivatives. ^ 15 cl, 2 dwg, 2 tbl, 15 ex |
