发明名称 |
POLYKETIDES UND DEREN HERSTELLUNG UND ANWENDUNG |
摘要 |
The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for inclusion in the larger product (rapamycin) produced by the enzymes encoded by the cluster. We have produced a mutant strain containing a rapamycin gene cluster in which the rapL gene is disabled. The strain does not naturally produce rapamycin but does so if fed with pipecolic acid. By feeding with alternative carboxylic acids we have produced variants of rapamycins. Tests have shown biological activity. |
申请公布号 |
DE69831943(T2) |
申请公布日期 |
2006.07.06 |
申请号 |
DE1998631943T |
申请日期 |
1998.05.28 |
申请人 |
BIOTICA TECHNOLOGY LTD., CAMBRIDGE |
发明人 |
LEADLAY, FRANCIS;STAUNTON, JAMES;KHAW, EE |
分类号 |
C12N15/00;C07D498/18;C07H17/08;C12N1/21;C12N9/88;C12N15/52;C12P19/62 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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