Pyrazole compounds

摘要

Compounds of formula (IA) or (IB) or a salt, N-oxide, hydrate or solvate thereof are inhibitors of HSP90, and are of value in the treatment of diseases responsive to HSP90 inhibition such as cancers. In the formulae, Ar is an aryl, aryl(C₁-C₆ alkyl), aryl(C₁-C₆ alkyl), heteroaryl, heteroarylaryl(C₁-C₆ alkyl), or heteroarylaryl(C₁-C₆ alkyl) group, any of which being optionally substituted in the aryl or heteroaryl part thereof; R₁, is hydrogen or optionally substituted C₁-C₆ alkyl; R₂ is hydrogen, optionally substituted cycloalkyl, cycloalkenyl, C₁-C₆ alkyl, C₁-C₆ alkenyl, or C₁-C₆ alkynyl; or a carboxyl, carboxamide or carboxyl ester group; and ring A is a non aromatic carbocyclic or heterocyclic ring wherein (i) a ring carbon is optionally substituted, and/or (ii) a ring nitrogen is optionally substituted by a group of formula -(Alk¹)_p (Cyc)_n-(Alk³)_m-(Z)_r-(Alk²)_s Q where Alk¹, Alk² and Alk³ are optionally substituted C₁-C₃ alkyl, Cyc is an optionally substituted carbocyclic or heterocyclic radical; m, n, p, r and s are independently 0 or 1, Z is -0-, -S-, -(C-O)-, -S02-, -C(-O)O-, -OC(-O)-, -NW-, -C(-O)NR^A-, -NR^AC(-O)-, -SO₂NR^A-, or -NR^ASO₂- wherein R^A is hydrogen or C₁-C₆ alkyl, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical.