发明名称 |
Azulene dimer-quenched, near-infrared fluorescent probes |
摘要 |
An intramolecularly-quenched, near-infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near-infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or bothours. Also disclosed are methods of using the intramolecularly-quenched, near-infrared fluorescence probes for in vivo optical imaging.
|
申请公布号 |
US2006147378(A1) |
申请公布日期 |
2006.07.06 |
申请号 |
US20050528634 |
申请日期 |
2005.12.15 |
申请人 |
TUNG CHING-HSUAN;WEISSLEDER RALPH;PHAM WELLINGTON |
发明人 |
TUNG CHING-HSUAN;WEISSLEDER RALPH;PHAM WELLINGTON |
分类号 |
A61K49/00;C07C51/347;C07C69/738;C07K1/13;C07K14/47;C07K16/46;C09B23/02 |
主分类号 |
A61K49/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|