METHOD OF PREPARING SILICA SPHERE CONTAINING LABELED MOLECULE

摘要

A novel method of efficiently and stably preparing a silica sphere containing a desired labeled molecule; a labeled-molecule-containing silica sphere obtained by the method; and a use of the silica sphere as a detection reagent. The labeled-molecule-containing silica sphere (5) is prepared through (a) a step in which a succinimidyl ester compound (1) comprising succinimide and a labeled molecule bonded thereto through an ester bond (-CO-O-) is reacted with a silica compound (2) having an amino group to yield a silica compound (3) containing the labeled molecule and (b) a step in which one of or a combination of two or more of such labeled-molecule-containing silica compounds (3) obtained in the step (a) is reacted with a silica compound (4).