PYRIMIDINYLISOXAZOL DERIVATIVE

摘要

An isoxazol derivative, or its pharmacologically acceptable salt, having an excellent P38MAP kinase inhibiting potency, the pyrimidinylisoxazol derivative represented by the formula: wherein R<SUP>1</SUP> is a hydrogen atom, lower alkyl, amino, halogen atom, lower alkoxy, etc.; R<SUP>2</SUP> is a substituted or unsubstituted aryl, etc.; R<SUP>3</SUP> is a hydrogen atom or lower alkyl; R<SUP>4</SUP> is a substituted or unsubstituted phenyl, etc.; and Y is -CH<SUB>2</SUB>-, -CO-, -CH(CH<SUB>3</SUB>)-, -O-, -NH-, etc.