| 摘要 |
The invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by Formula (1) as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer. |
| 申请人 |
PFIZER INC.,;CANCER RESEARCH TECHNOLOGY LTD.;STEINFELDT, HEIDI, MARIE;BORITZKI, THEODORE, JAMES;CALVERT, ALAN, HILARY;CURTIN, NICOLA, JANE;DEWJI, MOHAMED, RAZA;HOSTOMSKY, ZDENEK;JONES, CHRISTOPHER;KAUFMAN, RHONDA;KLAMERUS, KAREN, J.;NEWELL, DAVID, RICHARD;PLUMMER, ELIZABETH, RUTH;REICH, STEVEN, DAVID;STRATFORD, IAN, J.;THOMAS, HUW, DAVID;WILLIAMS, KAYE, JANINE |
发明人 |
STEINFELDT, HEIDI, MARIE;BORITZKI, THEODORE, JAMES;CALVERT, ALAN, HILARY;CURTIN, NICOLA, JANE;DEWJI, MOHAMED, RAZA;HOSTOMSKY, ZDENEK;JONES, CHRISTOPHER;KAUFMAN, RHONDA;KLAMERUS, KAREN, J.;NEWELL, DAVID, RICHARD;PLUMMER, ELIZABETH, RUTH;REICH, STEVEN, DAVID;STRATFORD, IAN, J.;THOMAS, HUW, DAVID;WILLIAMS, KAYE, JANINE |
