发明名称 |
Counterion exchange process for peptides |
摘要 |
The invention encompasses a process for purifying a peptide comprising loading a peptide onto a RP-HPLC column; washing the column with an aqueous solution of a pharmaceutically acceptable counterion salt; and eluting the peptide from the column with a solvent mixture of a organic solvent and an acid of the pharmaceutically acceptable counterion, wherein the aqueous solution has a pH of at least about 6.
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申请公布号 |
US2006148699(A1) |
申请公布日期 |
2006.07.06 |
申请号 |
US20050244135 |
申请日期 |
2005.10.04 |
申请人 |
TOVI AVI;EIDELMAN CHAIM;SHUSHAN SHIMON;ELSTER SHAI;ALON HAGI;IVCHENKO ALEXANDER;BUTILCA GABRIEL-MARCUS;ZAOVI GIL |
发明人 |
TOVI AVI;EIDELMAN CHAIM;SHUSHAN SHIMON;ELSTER SHAI;ALON HAGI;IVCHENKO ALEXANDER;BUTILCA GABRIEL-MARCUS;ZAOVI GIL |
分类号 |
A61K38/23;A61K38/08;A61K38/11;A61K38/24;A61K38/31 |
主分类号 |
A61K38/23 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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