发明名称 |
Methods of forming targeted liposomes loaded with a therapeutic agent |
摘要 |
The present invention provides for liposomes loaded with a therapeutic agent, which liposomes are targeted to a cell of interest by incubation with a targeting protein protein conjugated to a linker molecule comprising a hydrophobic domain, a hydrophilic polymer chain terminally attached to the hydrophobic domain, and a chemical group reactive to one or more functional groups on a protein molecule and attached to the hydrophilic polymer chain at a terminus contralateral to the hydrophobic domain, for a time sufficient to permit the hydrophobic domain to become stably associated with the liposome.
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申请公布号 |
US2006147513(A1) |
申请公布日期 |
2006.07.06 |
申请号 |
US20060363986 |
申请日期 |
2006.02.27 |
申请人 |
REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
PAPAHADJOPOULOS DEMETRIOS;HONG KEELUNG;ZHENG WEIWEN;KIRPOTIN DMITRI B. |
分类号 |
A61K9/127;C12N15/09;A61K9/00;A61K31/7105;A61K31/711;A61K47/10;A61K47/34;A61K47/48;A61K48/00;C07H21/00;C07H21/02;C07H21/04;C12N15/88 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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