A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme.
申请公布号
WO2004061079(A3)
申请公布日期
2006.07.06
申请号
WO2003US41037
申请日期
2003.12.23
申请人
ONYX PHARMACEUTICALS, INC.
发明人
SHEN, YUQIAO;LAQUERRE, SYLVIE;DELANEY, AMY, M.;OMER, CHARLES, A.
