Phthalazinone derivatives

摘要

Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NR^X or CR^XR^Y; if X=NR^X then n is 1 or 2 and if X=CR^XR^Y then n is 1; R^X is selected from the group consisting of H, optionally substituted C_1-20 alkyl, C_5-20 aryl, C_3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; R_Y is selected from H, hydroxy, amino; or R^X and R^Y may together form a spiro-C_3-7 cycloalkyl or heterocyclyl group; R^C1 and R^C2 are both hydrogen, or when X is CR^XR^Y, R^C1, R^C2, R^X and R^Y, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R¹ is selected from H and halo.