发明名称 Nucleic acid inhibitors of glutamate receptors
摘要 The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
申请公布号 US2006148746(A1) 申请公布日期 2006.07.06
申请号 US20050256726 申请日期 2005.10.24
申请人 NIU LI;HUANG ZHEN;SHI HUA;LIS JOHN T 发明人 NIU LI;HUANG ZHEN;SHI HUA;LIS JOHN T.
分类号 A61K48/00;C07H21/04;C12Q1/68 主分类号 A61K48/00
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