1,7-NAPHTHYRIDINES AS PDE4 INHIBITORS

摘要

There are provided according to the invention novel compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof: (I) wherein: R¹ is phenyl which may be unsubstituted or substituted by one or two substituents selected from fluorine, chlorine, C_1-2alkoxy-, -CN; phenyl fused to a 5-membered saturated ring containing one oxygen atom; pyridinyl which may be unsubstituted or substituted by one or two substituents selected from fluorine or chlorine; or C-linked pyrazolyl which may be unsubstituted or substituted by the substituent C_1-2alkyl; R² is C_1-4alkyl; R³ is C_1-2alkyl; and n is 0, 1 or 2.