发明名称 |
IMMUNOGLOBULINS WHITH POTENT AND BROAD ANTIVIRAL ACTIVITY |
摘要 |
A<SUB>.</SUB> (poly)peptide-Fe fusion molecule, such as an scFv-Fc<SUB>.</SUB> fusion molecule comprising an scFv fragment and an Fc region from an antibody, related nucleic acids, vectors, and host cells, and a method of inhibiting a viral infection in a mammal, which method comprises administering to a mammal in need thereof the fusion molecule, wherein the fusion molecule binds to an epitope of a viral envelope protein that is inaccessible to whole immunoglobulin molecules due to molecular steric hindrance, or a nucleic acid, optionally in the form of a vector, encoding same, wherein the nucleic acid or vector is optionally contained within a host cell. |
申请公布号 |
WO2006071206(A2) |
申请公布日期 |
2006.07.06 |
申请号 |
WO2004US31878 |
申请日期 |
2004.09.29 |
申请人 |
REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTTHE GOVERNMENT OF THE UNITED STATES OF AMERICA, ASH AND HUMAN SERVICES;DIMITROV, DIMITER, S.;ZHANG, MEI-YUN |
发明人 |
DIMITROV, DIMITER, S.;ZHANG, MEI-YUN |
分类号 |
A61K39/21;C07K16/08 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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