发明名称 |
POLYMERIC IMPLANTS, PREFERABLY CONTAINING A MIXTURE OF PEG AND PLG, FOR CONTROLLED RELEASE OF A GNRH |
摘要 |
<p>Controlled release compositions for controlling release of a GnRH molecule or a GnRH analog are provided. The compositions include a GnRH molecule or GnRH analog as an active agent, and a controlled release component for controlling release of the GnRH molecule or GnRH analog from the composition. The compositions provide a sustained mean steady state plasma concentration (Css) of the active agent of at least about 1.5 ng/mL for a period of at least about 48 hours when the composition is administered to a subject. In addition, the use of a controlled release component in the manufacture of a composition for the controlled release of a GnRH molecule or GnRH analog is provided. The controlled release component'is capable of providing a sustained mean steady state plasma concentration (C<SUB>38</SUB>) of the active agent of at. least about 1.5 ng/mL for a period of at least about 48 hours when the manufactured composition is administered to a subject. The controlled release component can include a polymeric material and/or a non-polymeric material. When the compositions are administered to a subject, for example when implanted, the compositions release the active agent in a controlled fashion. Methods for producing the compositions are also provided, as are methods of using the compositions to provide for controlled release of the GnRH molecule or GnRH analog in a subject. Preferred polymeric material is PLG or a copolymer of PLG and a PEG derivative such as methoxy PEG. Preferred non-polymeric material can be SAIB.</p> |
申请公布号 |
WO2006071208(A1) |
申请公布日期 |
2006.07.06 |
申请号 |
WO2004US43079 |
申请日期 |
2004.12.23 |
申请人 |
DURECT CORPORATION;BROWN, JAMES, E.;GIBSON, JOHN, W. |
发明人 |
BROWN, JAMES, E.;GIBSON, JOHN, W. |
分类号 |
A61K9/00;A61K9/16;A61K38/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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