Vitamin d3 lactone derivatives

摘要

A compound represented by the following Formula (1) that is effective for the treatment of Paget's disease of bone or hypercalcemia or a medically acceptable solvate thereof; [wherein R₁ refers to hydrogen atom, C₁-C₆ alkyl group optionally substituted with hydrogen group or C₁-C₆ alkoxy group optionally substituted with hydroxyl group, R^2a and R^2b refer to hydrogen atom, C₁-C₁₀ alkyl group optionally substituted with hydroxyl group, C₆-C₁₀ aryl group optionally substituted with hydroxyl group or C₇-C₁₂ aralkyl group optionally substituted with a hydroxyl group, or are combined to represent ethylene group. However, a compound in which R¹ is a hydrogen atom or a methyl group and R^2a and R^2b are hydrogen atoms is excluded].